{"id":7062,"date":"2020-08-18T17:29:24","date_gmt":"2020-08-18T15:29:24","guid":{"rendered":"https:\/\/dev2.ceraver.com\/actisurf-an-innovative-coating\/"},"modified":"2021-11-09T14:41:25","modified_gmt":"2021-11-09T13:41:25","slug":"actisurf-an-innovative-coating","status":"publish","type":"post","link":"https:\/\/www.ceraver.com\/en\/actisurf-an-innovative-coating\/","title":{"rendered":"ACTISURF – An Innovative Coating"},"content":{"rendered":"
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Bone regeneration and bacterial anti-adhesion<\/h1>
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\nThe two main challenges to faced when implanting a prosthesis lie in good tissue integration while preventing infection<\/strong>. In collaboration with chemical experts from the CNRS UMR 7244 unit, CERAVER developed and then industrialized a surface treatment process allowing a control of a cell response and an inhibition of bacterial adhesion under experimental conditions. Indeed, the radical grafting of a bioactive polymer, poly(sodium styrene sulfonate) onto prosthesis surface demonstrates continuously its excellent in vitro and in vivo results<\/strong> [1-5], opening the way to a new generation of bioactive prosthesis in several application fields<\/strong>.<\/p>\n

The objective of the \u201cACTISURF\u201d project is to offer a new generation of bioactive orthopedic prostheses. The goal is to promote bone regeneration around the prosthesis, while inhibiting bacterial adhesion<\/strong>. This technology is patented in Europe, the USA and Japan. Protein mediation allows control of the host response, thereby avoiding the creation of bacterial biofilm. This high value-added coating is currently under clinical investigation in France for orthopedic applications. Developments are underway in fields such as traumatology, dentistry, neurosurgery, cardio-vascular\u2026and so on.<\/p>\n

[1] A. Alcheikh, G. Pavon-Djavid, G. Helary, H. Petite, V. Migonney, et F. Anagnostou, \u00ab PolyNaSS grafting on titanium surfaces enhances osteoblast differentiation and inhibits Staphylococcus aureus adhesion \u00bb, J. Mater. Sci. Mater. Med., vol. 24, no 7, p. 1745\u20111754, juill. 2013.<\/em>
\n[2] A.-C. Cr\u00e9mieux, G. Pavon-Djavid, A. S. Mghir, G. H\u00e9lary, et V. Migonney, \u00ab Bioactive polymers grafted on silicone to prevent Staphylococcus aureus prosthesis adherence: in vitro and in vivo studies \u00bb, J Appl Biomater Biomech, vol. 3, no 1, p. 178\u201185, sept. 2003.<\/em>
\n[3] H. P. Felgueiras et al., \u00ab Bone tissue response induced by bioactive polymer functionalized Ti6Al4V surfaces: In vitro and in vivo study \u00bb, J. Colloid Interface Sci., vol. 491, p. 44\u201154, avr. 2017.<\/em>
\n[4] H. P. Felgueiras, I. B. Aissa, M. D. M. Evans, et V. Migonney, \u00ab Contributions of adhesive proteins to the cellular and bacterial response to surfaces treated with bioactive polymers: case of poly(sodium styrene sulfonate) grafted titanium surfaces \u00bb, J. Mater. Sci. Mater. Med., vol. 26, no 11, nov. 2015.<\/em>
\n[5] A.Leroux, J.K. Venkatesan, D.G. Castner, M. Cucchiarini, V. Migonney, \u00ab Analysis of early cellular responses of anterior cruciate ligament fibroblasts seeded on different molecular weight polycaprolactone films functionalized by a bioactive poly(sodium styrene sulfonate) polymer \u00bb, Biointerphases, 14, aout 2019.<\/em><\/p>\n\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div>

Read more...<\/h2>
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